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Chromatin Accessibility Impacts Transcriptional Reprogramming in Oocytes

1 Jul 2018

Abstract excerpt

Oocytes have a remarkable ability to reactivate silenced genes in somatic cells. However, it is not clear how the chromatin architecture of somatic cells affects this transcriptional reprogramming. Here, we investigated the relationship between the chromatin opening and transcriptional activation. We reveal changes in chromatin accessibility and their relevance to transcriptional reprogramming after...

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PMID: 29996092
DOI: 10.1016/j.celrep.2018.06.030

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