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Article

Potential Role of Brain-Derived Neurotrophic Factor and Dopamine Receptor D2 Gene Variants as Modifiers for the Susceptibility and Clinical Course of Wilson's Disease.

Neuromolecular medicine - 1 Sept 2018

Roy Shubhrajit, Pal Prosenjit, Ghosh Sampurna, Bhattacharya Sreyashi, Das Shyamal Kumar, Gangopadhyay Prasanta Kumar, Bavdekar Ashish, Ray Kunal, Sengupta Mainak, Ray Jharna

Abstract excerpt

Wilson's disease (WD), an inborn error of copper metabolism caused by mutations in the ATPase copper transporting beta (ATP7B) gene, manifests variable age of onset and different degrees of hepatic and neurological disturbances. This complex phenotypical outcome of a classical monogenic disease can possibly be explained by modifier loci regulating the clinical course of the disease. The brain-derived neurotropic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29992511
DOI: 10.1007/s12017-018-8501-2

Genes

BDNF
DRD2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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