Integrated omics approach for the identification of HDL structure-function relationships in PCSK9-related familial hypercholesterolemia.

doi:10.1016/j.jacl.2023.07.003

Article

Integrated omics approach for the identification of HDL structure-function relationships in PCSK9-related familial hypercholesterolemia.

Journal of clinical lipidology - 1 Jan 2000

Darabi Maryam, Lhomme Marie, Ponnaiah Maharajah, Pučić-Baković Maja, Guillas Isabelle, Frisdal Eric, Bittar Randa, Croyal Mikaël, Matheron-Duriez Lucrèce, Poupel Lucie, Bonnefont-Rousselot Dominique, Frere Corinne, Varret Mathilde, Krempf Michel, Cariou Bertrand, Lauc Gordan, Guerin Maryse, Carrie Alain, Bruckert Eric, Giral Philippe, Le Goff Wilfried, Kontush Anatol

Abstract excerpt

BACKGROUND: The role of proprotein convertase subtilisin/kexin type 9 (PCSK9) in dyslipidemia may go beyond its immediate effects on low-density lipoprotein receptor (LDL-R) activity. OBJECTIVE: This study aimed to assess PCSK9-derived alterations of high-density lipoprotein (HDL) physiology, which bear a potential to contribute to cardiovascular risk profile. METHODS: HDL was isolated from 33 patients with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hyperlipoproteinemia Type II

Integrated omics approach for the identification of HDL structure-function relationships in PCSK9-related familial hypercholesterolemia.

Abstract excerpt

Topics

Related research