Article
Activation of WNT/β-catenin signaling results in resistance to a dual PI3K/mTOR inhibitor in colorectal cancer cells harboring PIK3CA mutations.
International journal of cancer - 15 Jan 2019
Park Ye-Lim, Kim Hwang-Phill, Cho Young-Won, Min Dong-Wook, Cheon Seul-Ki, Lim Yoo Joo, Song Sang-Hyun, Kim Sung Jin, Han Sae-Won, Park Kyu Joo, Kim Tae-You
Abstract excerpt
PIK3CA is a frequently mutated gene in cancer, including about ~15 to 20% of colorectal cancers (CRC). PIK3CA mutations lead to activation of the PI3K/AKT/mTOR signaling pathway, which plays pivotal roles in tumorigenesis. Here, we investigated the mechanism of resistance of PIK3CA-mutant CRC cell lines to gedatolisib, a dual PI3K/mTOR inhibitor. Out of a panel of 29 CRC cell lines, we identified 7 harboring one...
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