Article
Whole genome sequencing and mutation rate analysis of trios with paternal dioxin exposure.
Human mutation - 1 Oct 2018
Ton Nguyen Dang, Nakagawa Hidewaki, Ha Nguyen Hai, Duong Nguyen Thuy, Nhung Vu Phuong, Hien Le Thi Thu, Hue Huynh Thi Thu, Hoang Nguyen Huy, Wong Jing Hao, Nakano Kaoru, Maejima Kazuhiro, Sasaki-Oku Aya, Tsunoda Tatsuhiko, Fujimoto Akihiro, Van Hai Nong
Abstract excerpt
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) or dioxin, is commonly considered the most toxic man-made substance. Dioxin exposure impacts human health and diseases, birth defects and teratogenesis were frequently observed in children of persons who have been exposed to dioxin. However, the impact of dioxin on human mutation rate in trios has not yet been elucidated at the whole genome level. To identify and...
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