Article
A novel genetic pathway for sudden cardiac death via defects in the transition between ventricular and conduction system cell lineages.
Cell - 1 Sept 2000
Nguyên-Trân V T, Kubalak S W, Minamisawa S, Fiset C, Wollert K C, Brown A B, Ruiz-Lozano P, Barrere-Lemaire S, Kondo R, Norman L W, Gourdie R G, Rahme M M, Feld G K, Clark R B, Giles W R, Chien K R
Abstract excerpt
HF-1 b, an SP1 -related transcription factor, is preferentially expressed in the cardiac conduction system and ventricular myocytes in the heart. Mice deficient for HF-1 b survive to term and exhibit normal cardiac structure and function but display sudden cardiac death and a complete penetrance of conduction system defects, including spontaneous ventricular tachycardia and a high incidence of AV block....
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