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Article

Personalized regression enables sample-specific pan-cancer analysis.

Bioinformatics (Oxford, England) - 1 Jul 2018

Lengerich Benjamin J, Aragam Bryon, Xing Eric P

Abstract excerpt

Motivation: In many applications, inter-sample heterogeneity is crucial to understanding the complex biological processes under study. For example, in genomic analysis of cancers, each patient in a cohort may have a different driver mutation, making it difficult or impossible to identify causal mutations from an averaged view of the entire cohort. Unfortunately, many traditional methods for genomic analysis seek...

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PMID: 29949997
DOI: 10.1093/bioinformatics/bty250
PMCID: PMC6022603

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