Article
TERTp mutation is associated with a shorter progression free survival in patients with aggressive histology subtypes of follicular-cell derived thyroid carcinoma.
Endocrine - 1 Sept 2018
Penna Gustavo C, Pestana Ana, Cameselle José Manuel, Momesso Denise, de Andrade Fernanda Accioly, Vidal Ana Paula Aguiar, Araujo Junior Mario Lucio, Melo Miguel, Fernandes Priscila Valverde, Corbo Rossana, Vaisman Mario, Sobrinho-Simões Manuel, Soares Paula, Vaisman Fernanda
Abstract excerpt
PURPOSE: Evaluate the impact of TERTp mutation on the outcomes after initial treatment of 45 patients with thyroid carcinomas derived from follicular cells (TCDFC) with aggressive histology, in which the role of this mutation is not yet well defined. METHODS: Analysis of the presence of TERTp (-124C > T and -146C > T), BRAF (V600E), and NRAS (Q 61R) mutations by Sanger sequencing and analysis of their correlation...
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