Article
Significant concordance of genetic variation that increases both the risk for obsessive-compulsive disorder and the volumes of the nucleus accumbens and putamen.
The British journal of psychiatry : the journal of mental science - 1 Jul 2018
Hibar Derrek P, Cheung Joshua W, Medland Sarah E, Mufford Mary S, Jahanshad Neda, Dalvie Shareefa, Ramesar Raj, Stewart Evelyn, van den Heuvel Odile A, Pauls David L, Knowles James A, Stein Dan J, Thompson Paul M
Abstract excerpt
BACKGROUND: Many studies have identified changes in the brain associated with obsessive-compulsive disorder (OCD), but few have examined the relationship between genetic determinants of OCD and brain variation.AimsWe present the first genome-wide investigation of overlapping genetic risk for OCD and genetic influences on subcortical brain structures. METHOD: Using single nucleotide polymorphism effect concordance...
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