Article
Childhood adiposity, adult adiposity, and the ACE gene insertion/deletion polymorphism: evidence of gene-environment interaction effects on adult blood pressure and hypertension status in adulthood.
Journal of hypertension - 1 Nov 2018
Sun Cong, Ponsonby Anne-Louise, Carlin John B, Bui Minh, Magnussen Costan G, Burns Trudy L, Lehtimaki Terho, Wardrop Nicole H, Juonala Markus, Viikari Jorma S A, Venn Alison J, Raitakari Olli T, Dwyer Terence
Abstract excerpt
BACKGROUND: Genetic variants may modify the associations of adiposity measures with blood pressure (BP) and hypertension. The insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene is an attractive candidate. AIMS: To examine interaction effects between I/D polymorphism and adiposity measures (BMI, waist circumference, waist-to-hip ratio, and skinfold thickness) during childhood and...
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