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Article

PROX1 is a transcriptional regulator of MMP14

18 Jun 2018

Abstract excerpt

The transcription factor PROX1 is essential for development and cell fate specification. Its function in cancer is context-dependent since PROX1 has been shown to play both oncogenic and tumour suppressive roles. Here, we show that PROX1 suppresses the transcription of MMP14, a metalloprotease involved in angiogenesis and cancer invasion, by binding and suppressing the activity of MMP14 promoter. Prox1 deletion...

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PMID: 29934628
DOI: 10.1038/s41598-018-27739-w

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