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Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow

18 Jun 2018

Abstract excerpt

Abstract Endothelial cells (ECs) contribute to haematopoietic stem cell (HSC) maintenance in bone marrow, but the differential contributions of EC subtypes remain unknown, owing to the lack of methods to separate with high purity arterial endothelial cells (AECs) from sinusoidal endothelial cells (SECs). Here we show that the combination of podoplanin (PDPN) and Sca-1 expression distinguishes AECs (CD45 − Ter119...

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PMID: 29934585
DOI: 10.1038/s41467-018-04726-3

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