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c-Myc is a novel Leishmania virulence factor by proxy that targets the host miRNA system and is essential for survival in human macrophages

22 Jun 2018

Abstract excerpt

Leishmania species are intracellular protozoan pathogens that have evolved to successfully infect and deactivate host macrophages. How this deactivation is brought about is not completely understood. Recently, microRNAs (miRNAs) have emerged as ubiquitous regulators of macrophage gene expression that contribute to shaping the immune responses to intracellular pathogens. Conversely, several pathogens have evolved...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29934305
DOI: 10.1074/jbc.ra118.002462

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