Article
Intermediate-length CAG repeat in ATXN2 is associated with increased risk for amyotrophic lateral sclerosis in Brazilian patients.
Neurobiology of aging - 1 Sept 2018
Tavares de Andrade Helen Maia, Cintra Vívian Pedigone, de Albuquerque Milena, Piccinin Camila Callegari, Bonadia Luciana Cardoso, Duarte Couteiro Rafael Esteves, Sabino de Oliveira Daniel, Claudino Rinaldo, Magno Gonçalves Marcos Vinicius, Dourado Mario Emilio Teixeira, de Souza Leonardo Cruz, Teixeira Antônio Lúcio, de Godoy Rousseff Prado Laura, Tumas Vitor, Bulle Oliveira Acary Souza, Nucci Anamarli, Lopes-Cendes Iscia, Marques Wilson, França Marcondes C
Abstract excerpt
Intermediate-length cytosine-adenine-guanine nucleotide repeat expansions in the ATXN2 gene (which encodes for the protein Ataxin-2) have been linked to increased risk for amyotrophic lateral sclerosis (ALS) in different populations. There is no such study in the Brazilian population, which has a mixed ethnic background. We have thus selected 459 patients with ALS (372 Sporadic ALS and 87 Familial ALS) and 468...
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