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Article

Upregulation of the EMT marker vimentin is associated with poor clinical outcome in acute myeloid leukemia.

Journal of translational medicine - 20 Jun 2018

Wu Sharon, Du Yang, Beckford John, Alachkar Houda

Abstract excerpt

BACKGROUND: Vimentin (VIM) is a type III intermediate filament that maintains cell integrity, and is involved in cell migration, motility and adhesion. When overexpressed in solid cancers, vimentin drives epithelial to mesenchymal transition (EMT) and ultimately, metastasis. The effects of its overexpression in AML are unclear. METHODS: In this study, we analyzed the TCGA data of 173 AML patients for which...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Leukemic

Share to Leukemia, Myeloid, Acute

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Source

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Identifiers

PMID: 29925392
DOI: 10.1186/s12967-018-1539-y
PMCID: PMC6009962

Genes

VIM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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