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Article

A quest for clarity in bone erosion: The role of sequestosome 1 in Paget's disease of bone.

The Journal of biological chemistry - 15 Jun 2018

Michalski Megan N, Williams Bart O

Abstract excerpt

Alterations in the SQSTM1 gene are a putative cause of Paget's disease of bone, yet results are conflicting about how these mutations impact osteoclasts, the cell type believed to be the main pathological contributor. In this issue of JBC, Zach et al. provide important new evidence that the protein encoded by SQSTM1, p62, negatively regulates osteoclastogenesis and demonstrate that aged p62-deficient mice develop...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29907733
DOI: 10.1074/jbc.H118.003689
PMCID: PMC6005432

Genes

SQSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A quest for clarity in bone erosion: The role of sequestosome 1 in Paget's disease of bone.PMID 29907733Read ↗

New insights into the role of sequestosome 1/p62 mutant proteins in the pathogenesis of Paget's disease of bone.Semantic proximity Read ↗

Recent advances in understanding the molecular basis of Paget disease of bone.Semantic proximity Read ↗

SQSTM1 and Paget's disease of bone.Semantic proximity Read ↗

Paget's disease of bone: an update.Semantic proximity Read ↗

Paget's disease: epidemiology and pathophysiology.Semantic proximity Read ↗

The adaptor protein p62/SQSTM1 in osteoclast signaling pathwaysSemantic proximity Read ↗

Latest developments in Paget's disease of bone.Semantic proximity Read ↗

Zoledronic acid prevents pagetic-like lesions and accelerated bone loss in the p62P394L mouse model of Paget's disease.Semantic proximity Read ↗

p62/sequestosome 1 deficiency accelerates osteoclastogenesis in vitro and leads to Paget’s disease–like bone phenotypes in miceSemantic proximity Read ↗

A mutation in p62 protein (p. R321C), associated to Paget's disease of bone, causes a blockade of autophagy and an activation of NF-kB pathway.Semantic proximity Read ↗

Sequestosome 1 (SQSTM1) mutations in Paget's disease of bone from the United States.Semantic proximity Read ↗

Advances in the genetics of Paget's disease of bone: from pathophysiology, diagnosis to clinical implications.Semantic proximity Read ↗

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