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An Association Between Core Mutations in Hepatitis B Virus Genotype F1b and Hepatocellular Carcinoma in Alaskan Native People.

Hepatology (Baltimore, Md.) - 1 Jan 2019

Hayashi Sanae, Khan Anis, Simons Brenna C, Homan Chriss, Matsui Takeshi, Ogawa Kenji, Kawashima Keigo, Murakami Shuko, Takahashi Satoru, Isogawa Masanori, Ikeo Kazuho, Mizokami Masashi, McMahon Brian J, Tanaka Yasuhito

Abstract excerpt

Hepatitis B virus (HBV) genotype F1b infection is strongly associated with hepatocellular carcinoma (HCC) in young Alaskan Native (AN) people. However, the mechanisms by which genotype F1b causes HCC are unclear. Here, we analyzed the clinical and virological significance of genotype F1b in long-term serial samples from 20 HCC patients with HBV infection. Complete sequence analyses revealed that all isolates were...

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PMID: 29893492
DOI: 10.1002/hep.30111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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