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Article

Direct activation of a phospholipase by cyclic GMP-AMP in El Tor <i>Vibrio cholerae</i>

11 Jun 2018

Abstract excerpt

Significance Second messengers are employed by all organisms to regulate fundamental behaviors, including biofilm formation, motility, metabolism, and pathogenesis in bacteria. We have identified a phospholipase in the El Tor Vibrio cholerae biotype, responsible for the current cholera pandemic, that is directly activated by the second messenger 3′, 3′-cyclic GMP-AMP (cGAMP). Discovery of this proteinaceous...

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PMID: 29891656
DOI: 10.1073/pnas.1801233115

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