Article
Postmortem Genetic Testing for Cardiac Ion Channelopathies in Stillbirths.
Circulation. Genomic and precision medicine - 1 Jan 2018
Munroe Patricia B, Addison Shea, Abrams Dominic J, Sebire Neil J, Cartwright James, Donaldson Ian, Cohen Marta M, Mein Charles, Tinker Andrew, Harmer Stephen C, Aziz Qadeer, Terry Anna, Struebig Monika, Warren Helen R, Vadgama Bhumita, Fowler Darren J, Peebles Donald, Taylor Andrew M, Lally Peter J, Thayyil Sudhin
Abstract excerpt
BACKGROUND: Although stillbirth is a significant health problem worldwide, the definitive cause of death remains elusive in many cases, despite detailed autopsy. In this study of partly explained and unexplained stillbirths, we used next-generation sequencing to examine an extended panel of 35 candidate genes known to be associated with ion channel disorders and sudden cardiac death. METHODS AND RESULTS: We...
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