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Application of antisense oligonucleotide drugs in amyotrophic lateral sclerosis and Huntington’s disease

21 Jan 2025

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) and Huntington's disease (HD) are diverse in clinical presentation and are caused by complex and multiple factors, including genetic mutations and environmental factors. Numerous therapeutic approaches have been developed based on the genetic causes and potential mechanisms of ALS and HD. Currently, available treatments for various neurodegenerative diseases can alleviate...

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PMID: 39838446
DOI: 10.1186/s40035-025-00466-9

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