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Article

A novel prognostic signature contributes to precision treatment in colon adenocarcinoma with KRAS mutation.

European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) - 1 Nov 2023

Dong Weiwei, Zhang He, Li Qingyan, Guan Na, Yun Chao, Zhao Huixia, Zhang Fengyun, Zeng Zhiyan, Hu Yanyan, Li Qiuwen, Yang Jingwen, Ma Zihuan, Chen Meiling, Xiao Wenhua

Abstract excerpt

BACKGROUND: Approximately 40% of colon cancer harbor Kirsten rat sarcoma viral oncogene ( KRAS ) mutations, but the prognostic value of KRAS mutations in colon cancer is still controversial. METHODS: We enrolled 412 colon adenocarcinoma (COAD) patients with KRAS mutations, 644 COAD patients with KRAS wild-type and 357 COAD patients lacking information on KRAS status from five independent cohorts. A random forest...

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PMID: 37310401
DOI: 10.1097/CEJ.0000000000000819

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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