Article
The uptake of presymptomatic genetic testing in hereditary breast-ovarian cancer and Lynch syndrome: a systematic review of the literature and implications for clinical practice.
Familial cancer - 1 Jan 2019
Menko Fred H, Ter Stege Jacqueline A, van der Kolk Lizet E, Jeanson Kiki N, Schats Winnie, Moha Daoud Ait, Bleiker Eveline M A
Abstract excerpt
Following the identification in a proband of a germline BRCA1/BRCA2 mutation in hereditary breast-ovarian cancer (HBOC) or a DNA mismatch repair gene mutation in Lynch syndrome (LS) he or she will be asked to inform at-risk family members about the option for presymptomatic DNA testing. However, in clinical practice multiple factors may complicate the process of information sharing. We critically evaluated...
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