Coexpression of p-IGF-1R and MMP-7 Modulates Panitumumab and Cetuximab Efficacy in RAS Wild-Type Metastatic Colorectal Cancer Patients.

doi:10.1016/j.neo.2018.05.004

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Article

Coexpression of p-IGF-1R and MMP-7 Modulates Panitumumab and Cetuximab Efficacy in RAS Wild-Type Metastatic Colorectal Cancer Patients.

Neoplasia (New York, N.Y.) - 1 Jul 2018

Alonso Vicente, Escudero Pilar, Fernández-Martos Carlos, Salud Antonia, Méndez Miguel, Gallego Javier, Rodriguez Jose-R, Martín-Richard Marta, Fernández-Plana Julen, Manzano Hermini, Méndez José-Carlos, Zanui Monserrat, Falcó Esther, Gil-Raga Mireia, Rojo Federico, Cuatrecasas Miriam, Feliu Jaime, García-Albéniz Xabier, Maurel Joan

Abstract excerpt

INTRODUCTION: The coexpression of pIGF-1R and MMP-7 (double-positive phenotype, DP) correlates with poor overall survival (OS) in KRAS wild-type (WT) (exon 2) metastatic colorectal cancer (mCRC) patients treated with irinotecan-cetuximab in second/third line. METHODS: We analyzed two prospective biomarker design trials of newly diagnosed RAS-WT mCRC patients treated with panitumumab-FOLFOX6 (PULSE trial;...

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Identifiers

PMID: 29842993
DOI: 10.1016/j.neo.2018.05.004
PMCID: PMC6030389

Genes

KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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