Article
Differences in pathogenicity and virulence of Trypanosoma brucei gambiense field isolates in experimentally infected Balb/C mice.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Sept 2018
Kaboré Jacques, Camara Oumou, Koffi Mathurin, Sanou Djénéba, Ilboudo Hamidou, Sakandé Hassane, Camara Mamadou, De Meeûs Thierry, Ravel Sophie, Belem Adrien Marie Gaston, MacLeod Annette, Bucheton Bruno, Jamonneau Vincent, Thévenon Sophie
Abstract excerpt
Trypanosoma brucei gambiense (T. b. gambiense) is the major causative agent of human African trypanosomiasis (HAT). A great variety of clinical outcomes have been observed in West African foci, probably due to complex host-parasite interactions. In order to separate the roles of parasite genetic diversity and host variability, we have chosen to precisely characterize the pathogenicity and virulence of T. b....
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