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Article

Analysis of Potential Alterations Affecting SETBP1 as a Novel Contributing Mechanism to Inhibit PP2A in Colorectal Cancer Patients.

World journal of surgery - 1 Nov 2018

Torrejón Blanca, Cristóbal Ion, Caramés Cristina, Prieto-Potín Iván, Chamizo Cristina, Santos Andrea, Sanz-Alvarez Marta, Serna-Blasco Roberto, Luque Melania, Madoz-Gúrpide Juan, Rojo Federico, García-Foncillas Jesús

Abstract excerpt

BACKGROUND: The functional loss of the tumor suppressor protein phosphatase 2A (PP2A) occurs in a wide variety of human cancers including colorectal cancer (CRC), and SET overexpression has been reported as a key contributing mechanism to inhibit PP2A. Although SET binding protein 1 (SETBP1) overexpression and gain of function mutations have been described in several hematological malignancies as common events...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29796729
DOI: 10.1007/s00268-018-4684-9

Genes

SETBP1
SET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 11 closest

Analysis of Potential Alterations Affecting SETBP1 as a Novel Contributing Mechanism to Inhibit PP2A in Colorectal Cancer Patients.PMID 29796729Read ↗

SET binding protein 1 (SETBP1) suppresses cell proliferation in estrogen receptor-positive breast cancer.Semantic proximity Read ↗

Identification of a novel de novo mutation of SETBP1 and new findings of SETBP1 in tumorgenesis.Semantic proximity Read ↗

The interaction of SET and protein phosphatase 2A as target for cancer therapySemantic proximity Read ↗

Clinicopathological significance and prognostic value of polypyrimidine tract binding protein 1 (PTBP1) in gastric cancerSemantic proximity Read ↗

CIP2A Inhibits PP2A in Human MalignanciesSemantic proximity Read ↗

PPP2R1B gene alterations inhibit interaction of PP2A-Abeta and PP2A-C proteins in colorectal cancers.Semantic proximity Read ↗

Protein phosphatase 1 in tumorigenesis: is it worth a closer look?Semantic proximity Read ↗

Overexpression of SET is a recurrent event associated with poor outcome and contributes to protein phosphatase 2A inhibition in acute myeloid leukemiaSemantic proximity Read ↗

Cancerous inhibitor of PP2A (CIP2A) at diagnosis of chronic myeloid leukemia is a critical determinant of disease progressionSemantic proximity Read ↗

Functional importance of PP2A regulatory subunit loss in breast cancer.Semantic proximity Read ↗

The concept of the okadaic acid class of tumor promoters is revived in endogenous protein inhibitors of protein phosphatase 2A, SET and CIP2A, in human cancersSemantic proximity Read ↗

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