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Article

Multi-omic molecular profiling of lung cancer in COPD.

The European respiratory journal - 1 Jul 2018

Sandri Brian J, Kaplan Adam, Hodgson Shane W, Peterson Mark, Avdulov Svetlana, Higgins LeeAnn, Markowski Todd, Yang Ping, Limper Andrew H, Griffin Timothy J, Bitterman Peter, Lock Eric F, Wendt Chris H

Abstract excerpt

Chronic obstructive pulmonary disease (COPD) is a known risk factor for developing lung cancer but the underlying mechanisms remain unknown. We hypothesise that the COPD stroma contains molecular mechanisms supporting tumourigenesis.We conducted an unbiased multi-omic analysis to identify gene expression patterns that distinguish COPD stroma in patients with or without lung cancer. We obtained lung tissue from...

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Identifiers

PMID: 29794131
DOI: 10.1183/13993003.02665-2017
PMCID: PMC6618293

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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