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Article

Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for the EsxW Beijing variant in Vietnam.

Nature genetics - 1 Jun 2018

Holt Kathryn E, McAdam Paul, Thai Phan Vuong Khac, Thuong Nguyen Thuy Thuong, Ha Dang Thi Minh, Lan Nguyen Ngoc, Lan Nguyen Huu, Nhu Nguyen Thi Quynh, Hai Hoang Thanh, Ha Vu Thi Ngoc, Thwaites Guy, Edwards David J, Nath Artika P, Pham Kym, Ascher David B, Farrar Jeremy, Khor Chiea Chuen, Teo Yik Ying, Inouye Michael, Caws Maxine, Dunstan Sarah J

Abstract excerpt

To examine the transmission dynamics of Mycobacterium tuberculosis (Mtb) isolated from tuberculosis patients in Ho Chi Minh City, Vietnam, we sequenced the whole genomes of 1,635 isolates and compared these with 3,144 isolates from elsewhere. The data identify an underlying burden of disease caused by the endemic Mtb lineage 1 associated with the activation of long-term latent infection, and a threefold higher...

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Identifiers

PMID: 29785015
DOI: 10.1038/s41588-018-0117-9
PMCID: PMC6143168

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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