Article
Neuronal activity regulates DROSHA via autophagy in spinal muscular atrophy.
Scientific reports - 21 May 2018
Gonçalves Inês do Carmo G, Brecht Johanna, Thelen Maximilian P, Rehorst Wiebke A, Peters Miriam, Lee Hyun Ju, Motameny Susanne, Torres-Benito Laura, Ebrahimi-Fakhari Darius, Kononenko Natalia L, Altmüller Janine, Vilchez David, Sahin Mustafa, Wirth Brunhilde, Kye Min Jeong
Abstract excerpt
Dysregulated miRNA expression and mutation of genes involved in miRNA biogenesis have been reported in motor neuron diseases including spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS). Therefore, identifying molecular mechanisms governing miRNA expression is important to understand these diseases. Here, we report that expression of DROSHA, which is a critical enzyme in the microprocessor...
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