Article
Mutational analysis of epidermal and hyperproliferative type I keratins in mild and moderate psoriasis vulgaris patients: a possible role in the pathogenesis of psoriasis along with disease severity.
Human genomics - 21 May 2018
Elango Tamilselvi, Sun Jingying, Zhu Caihong, Zhou Fusheng, Zhang Yaohua, Sun Liangdan, Yang Sen, Zhang Xuejun
Abstract excerpt
BACKGROUND: Mutations in keratin proteins have been vastly associated with a wide array of genodermatoses; however, mutations of keratins in psoriasis have not been fully investigated. The main aim of the current research was to identify the mutation in K14, K10, K16, and K17 genes in two stages of psoriasis patients. METHODS: Ninety-six psoriatic skin biopsies were collected. mRNA transcript of K14, K10, K16,...
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