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Article

Glycosylation of Cblns attenuates their receptor binding.

Brain research - 1 Sept 2018

Rong Yongqi, Bansal Parmil K, Wei Peng, Guo Hong, Correia Kristen, Parris Jennifer, Morgan James I

Abstract excerpt

Cbln1 is the prototype of a family (Cbln1-Cbln4) of secreted glycoproteins and is essential for normal synapse structure and function in cerebellum by bridging presynaptic Nrxn to postsynaptic Grid2. Here we report the effects of glycosylation on the in vitro receptor binding properties of Cblns. Cbln1, 2 and 4 harbor two N-linked glycosylation sites, one at the N-terminus is in a region implicated in Nrxn...

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Identifiers

PMID: 29782851
DOI: 10.1016/j.brainres.2018.05.022
PMCID: PMC6026032

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