Article
Disease Heritability Inferred from Familial Relationships Reported in Medical Records.
Cell - 14 Jun 2018
Polubriaginof Fernanda C G, Vanguri Rami, Quinnies Kayla, Belbin Gillian M, Yahi Alexandre, Salmasian Hojjat, Lorberbaum Tal, Nwankwo Victor, Li Li, Shervey Mark M, Glowe Patricia, Ionita-Laza Iuliana, Simmerling Mary, Hripcsak George, Bakken Suzanne, Goldstein David, Kiryluk Krzysztof, Kenny Eimear E, Dudley Joel, Vawdrey David K, Tatonetti Nicholas P
Abstract excerpt
Heritability is essential for understanding the biological causes of disease but requires laborious patient recruitment and phenotype ascertainment. Electronic health records (EHRs) passively capture a wide range of clinically relevant data and provide a resource for studying the heritability of traits that are not typically accessible. EHRs contain next-of-kin information collected via patient emergency contact...
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