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Article

Translation inhibition corrects aberrant localization of mutant alanine-glyoxylate aminotransferase: possible therapeutic approach for hyperoxaluria.

Journal of molecular medicine (Berlin, Germany) - 1 Jul 2018

Belostotsky Ruth, Lyakhovetsky Roman, Sherman Michael Y, Shkedy Fanny, Tzvi-Behr Shimrit, Bar Roi, Hoppe Bernd, Reusch Björn, Beck Bodo B, Frishberg Yaacov

Abstract excerpt

Primary hyperoxaluria type 1 is a severe kidney stone disease caused by abnormalities of the peroxisomal alanine-glyoxylate aminotransferase (AGT). The most frequent mutation G170R results in aberrant mitochondrial localization of the active enzyme. To evaluate the population of peroxisome-localized AGT, we developed a quantitative Glow-AGT assay based on the self-assembly split-GFP approach and used it to...

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PMID: 29777253
DOI: 10.1007/s00109-018-1651-8

Genes

AGT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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