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Article

A Kv4.2 truncation mutation in a patient with temporal lobe epilepsy.

Neurobiology of disease - 1 Nov 2006

Singh Baljinder, Ogiwara Ikuo, Kaneda Makoto, Tokonami Natsuko, Mazaki Emi, Baba Koichi, Matsuda Kazumi, Inoue Yushi, Yamakawa Kazuhiro

Abstract excerpt

Temporal lobe epilepsy (TLE) has a multifactorial etiology involving developmental, environmental, and genetic components. Here, we report a voltage-gated potassium channel gene mutation found in a TLE patient, namely a Kv4.2 truncation mutation. Kv4.2 channels, encoded by the KCND2 gene, mediate A currents in the brain. The identified mutation corresponds to an N587fsX1 amino acid change, predicted to produce a...

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Source

Identifiers

PMID: 16934482
DOI: 10.1016/j.nbd.2006.07.001

Genes

KCND2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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