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Article

Pretreatment drug resistance in a large countrywide Ethiopian HIV-1C cohort: a comparison of Sanger and high-throughput sequencing.

Scientific reports - 15 May 2018

Telele Nigus Fikrie, Kalu Amare Worku, Gebre-Selassie Solomon, Fekade Daniel, Abdurahman Samir, Marrone Gaetano, Neogi Ujjwal, Tegbaru Belete, Sönnerborg Anders

Abstract excerpt

Baseline plasma samples of 490 randomly selected antiretroviral therapy (ART) naïve patients from seven hospitals participating in the first nationwide Ethiopian HIV-1 cohort were analysed for surveillance drug resistance mutations (sDRM) by population based Sanger sequencing (PBSS). Also next generation sequencing (NGS) was used in a subset of 109 baseline samples of patients. Treatment outcome after 6- and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29765082
DOI: 10.1038/s41598-018-25888-6
PMCID: PMC5954158

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