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Identification of potential crucial genes and construction of microRNA-mRNA negative regulatory networks in osteosarcoma

9 May 2018

Abstract excerpt

BACKGROUND: This study aimed to identify potential crucial genes and construction of microRNA-mRNA negative regulatory networks in osteosarcoma by comprehensive bioinformatics analysis. METHODS: Data of gene expression profiles (GSE28424) and miRNA expression profiles (GSE28423) were downloaded from GEO database. The differentially expressed genes (DEGs) and miRNAs (DEMIs) were obtained by R Bioconductor...

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PMID: 29760609
DOI: 10.1186/s41065-018-0061-9

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