Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genomic evidence that the live Chlamydia abortus vaccine strain 1B is not attenuated and has the potential to cause disease.

Vaccine - 14 Jun 2018

Longbottom David, Sait Michelle, Livingstone Morag, Laroucau Karine, Sachse Konrad, Harris Simon R, Thomson Nicholas R, Seth-Smith Helena M B

Abstract excerpt

BACKGROUND: The live, temperature-attenuated vaccine strain 1B of Chlamydia abortus, the aetiological agent of ovine enzootic abortion (OEA), has been implicated in cases of vaccine breakdown. The aim of this study was to understand the nature of this attenuation through sequencing of the vaccine parent strain (AB7) and the derived mutant strains 1B and 1H, as well as to clarify the role of the vaccine strain in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Abortion, Veterinary
Share to Bacterial Vaccines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chlamydia

Share to Chlamydia Infections

Share to Methylnitronitrosoguanidine

Share to Mutagens

Share to Sheep Diseases

Share to Vaccines, Attenuated

Source

Open in PubMed Open full text

Identifiers

PMID: 29759381
DOI: 10.1016/j.vaccine.2018.05.042
PMCID: PMC6005232

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Genomic evidence that the live Chlamydia abortus vaccine strain 1B is not attenuated and has the potential to cause disease.PMID 29759381Read ↗

Evidence of Chlamydophila abortus vaccine strain 1B as a possible cause of ovine enzootic abortion.Semantic proximity Read ↗

European Chlamydia abortus livestock isolate genomes reveal unusual stability and limited diversity, reflected in geographical signatures.Semantic proximity Read ↗

Genome Report-A Genome Sequence Analysis of the RB51 Strain of Brucella abortus in the Context of Its Vaccine Properties.Semantic proximity Read ↗

High-resolution melt PCR analysis for rapid identification of Chlamydia abortus live vaccine strain 1B among C. abortus strains and field isolates.Semantic proximity Read ↗

Genomic analysis of an attenuated Chlamydia abortus live vaccine strain reveals defects in central metabolism and surface proteins.Semantic proximity Read ↗

Pathogenic outcome following experimental infection of sheep with Chlamydia abortus variant strains LLG and POSSemantic proximity Read ↗

Genomic and pathogenic studies on a glycoprotein E variant field isolate of bovine herpesvirus 1.Semantic proximity Read ↗

A Brucella melitensis high-temperature-requirement A (htrA) deletion mutant is attenuated in goats and protects against abortion.Semantic proximity Read ↗

Virulence attenuation and live vaccine potential of aroA, crp cdt cya, and plasmid-cured mutants of Salmonella enterica serovar Abortusovis in mice and sheep.Semantic proximity Read ↗

Natural IS711 insertion causing omp31 gene inactivation in Brucella ovis.Semantic proximity Read ↗

Bacterial survival, lymph node changes, and immunologic responses of cattle vaccinated with standard and mutant strains of Brucella abortus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.