Article
Transmission of molecularly undetectable circulating parasite clones leads to high infection complexity in mosquitoes post feeding.
International journal for parasitology - 1 Jul 2018
Grignard Lynn, Gonçalves Bronner P, Early Angela M, Daniels Rachel F, Tiono Alfred B, Guelbéogo Wamdaogo M, Ouédraogo Alphonse, van Veen Elke M, Lanke Kjerstin, Diarra Amidou, Nebie Issa, Sirima Sodiomon B, Targett Geoff A, Volkman Sarah K, Neafsey Daniel E, Wirth Dyann F, Bousema Teun, Drakeley Chris
Abstract excerpt
Plasmodium falciparum malaria infections often comprise multiple distinct parasite clones. Few datasets have directly assessed infection complexity in humans and mosquitoes they infect. Examining parasites using molecular tools may provide insights into the selective transmissibility of isolates. Using capillary electrophoresis genotyping and next generation amplicon sequencing, we analysed complexity of parasite...
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