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Article

HBV subgenotypes F1b and F4 replication induces an incomplete autophagic process in hepatocytes: Role of BCP and preCore mutations.

PloS one - 1 Jan 2018

Elizalde María Mercedes, Pérez Paula Soledad, Sevic Ina, Grasso Daniel, Ropolo Alejandro, Barbini Luciana, Campos Rodolfo Héctor, Vaccaro María Inés, Flichman Diego Martín

Abstract excerpt

Hepatitis B virus (HBV) genotypes and mutants have been associated with differences in clinical and virological characteristics. Autophagy is a cellular process that degrades long-lived proteins and damaged organelles. Viruses have evolved mechanisms to alter this process to survive in host cells. In this work, we studied the modulation of autophagy by the replication of HBV subgenotypes F1b and F4, and the...

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Share to Autophagy
Share to DNA, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis B virus

Share to Hepatocytes

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Share to Promoter Regions, Genetic

Share to Proteolysis

Share to Virus Replication

Source

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Identifiers

PMID: 29738548
DOI: 10.1371/journal.pone.0197109
PMCID: PMC5940199

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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