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Article

Simulated night shift work induces circadian misalignment of the human peripheral blood mononuclear cell transcriptome

7 May 2018

Abstract excerpt

Misalignment of the endogenous circadian timing system leads to disruption of physiological rhythms and may contribute to the development of the deleterious health effects associated with night shift work. However, the molecular underpinnings remain to be elucidated. Here, we investigated the effect of a 4-day simulated night shift work protocol on the circadian regulation of the human transcriptome. Repeated...

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PMID: 29735673
DOI: 10.1073/pnas.1720719115

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