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Blood transcriptome based biomarkers for human circadian phase

20 Feb 2017

Abstract excerpt

Diagnosis and treatment of circadian rhythm sleep-wake disorders both require assessment of circadian phase of the brain’s circadian pacemaker. The gold-standard univariate method is based on collection of a 24-hr time series of plasma melatonin, a suprachiasmatic nucleus-driven pineal hormone. We developed and validated a multivariate whole-blood mRNA-based predictor of melatonin phase which requires few...

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PMID: 28218891
DOI: 10.7554/elife.20214

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