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In vitro-induced erythromycin resistance facilitates cross-resistance to the novel fluoroketolide, solithromycin, in Staphylococcus aureus.

FEMS microbiology letters - 1 Jun 2018

Yao Weiming, Xu Guangjian, Bai Bing, Wang Hongyan, Deng Minggui, Zheng Jinxin, Li Duoyun, Deng Xiangbin, Liu Xiaojun, Lin Zhiwei, Chen Zhong, Li Guiqiu, Deng Qiwen, Yu Zhijian

Abstract excerpt

The aim of this study was to determine whether in vitro induced erythromycin resistance facilitates the cross-resistance to the novel fluoroketolide, solithromycin, in Staphylococcus aureus. Four strains of methicillin-susceptible S. aureus strains S2, S3, S5 and S7 were successfully induced to establish erythromycin-resistant strains by continuous in vitro culture with erythromycin. Mutations at drug binding...

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PMID: 29733362
DOI: 10.1093/femsle/fny116

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