BRCA mutations and their influence on pathological complete response and prognosis in a clinical cohort of neoadjuvantly treated breast cancer patients.

doi:10.1007/s10549-018-4797-8

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BRCA mutations and their influence on pathological complete response and prognosis in a clinical cohort of neoadjuvantly treated breast cancer patients.

Breast cancer research and treatment - 1 Aug 2018

Wunderle Marius, Gass Paul, Häberle Lothar, Flesch Vivien M, Rauh Claudia, Bani Mayada R, Hack Carolin C, Schrauder Michael G, Jud Sebastian M, Emons Julius, Erber Ramona, Ekici Arif B, Hoyer Juliane, Vasileiou Georgia, Kraus Cornelia, Reis Andre, Hartmann Arndt, Lux Michael P, Beckmann Matthias W, Fasching Peter A, Hein Alexander

Abstract excerpt

PURPOSE: BRCA1/2 mutations influence the molecular characteristics and the effects of systemic treatment of breast cancer. This study investigates the impact of germline BRCA1/2 mutations on pathological complete response and prognosis in patients receiving neoadjuvant systemic chemotherapy. METHODS: Breast cancer patients were tested for a BRCA1/2 mutation in clinical routine work and were treated with...

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PMID: 29725888
DOI: 10.1007/s10549-018-4797-8

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BRCA1
BRCA2

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