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Article

Reversal of the hair loss phenotype by modulating the estradiol-ANGPT2 axis in the mouse model of female pattern hair loss.

Journal of dermatological science - 1 Jul 2018

Endo Yujiro, Obayashi Yuko, Ono Tomoji, Serizawa Tetsushi, Murakoshi Michiaki, Ohyama Manabu

Abstract excerpt

BACKGROUND: Despite high demand for a remedy, the treatment options for female pattern hair loss (FPHL) are limited. FPHL is frequent in postmenopausal women. In ovariectomized (OVX) mice, which lack β-estradiol (E2) and manifest hair loss mimicking FPHL, E2 supplementation has been shown to increase hair density. However, the mechanism by which E2 exhibits its biological activity remains elusive. OBJECTIVE: To...

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Source

Identifiers

PMID: 29724581
DOI: 10.1016/j.jdermsci.2018.04.001

Genes

ANGPT2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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