Article
Elucidation of the TMab-6 Monoclonal Antibody Epitope Against Telomerase Reverse Transcriptase.
Monoclonal antibodies in immunodiagnosis and immunotherapy - 1 Jun 2019
Kaneko Mika K, Yamada Shinji, Itai Shunsuke, Chang Yao-Wen, Nakamura Takuro, Yanaka Miyuki, Harada Hiroyuki, Suzuki Hiroyoshi, Kato Yukinari
Abstract excerpt
Telomerase reverse transcriptase (TERT) and mutations of the TERT promoter are significant in the pathogenesis of 1p/19q-codeleted oligodendrogliomas and isocitrate dehydrogenase gene wild-type glioblastomas, as well as melanomas and squamous cell carcinomas. We previously developed an antihuman TERT monoclonal antibody (mAb), TMab-6, which is applicable in immunohistochemistry for human tissues. However, the...
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