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Article

ABCB1 gene polymorphisms are associated with adverse reactions in fluoropyrimidine-treated colorectal cancer patients.

Pharmacogenomics - 1 Dec 2010

Gonzalez-Haba Eva, García Maria I, Cortejoso Lucia, López-Lillo Carolina, Barrueco Nélida, García-Alfonso Pilar, Alvarez Sonsoles, Jiménez Jose L, Martín María L, Muñóz-Fernández Maria A, Sanjurjo María, López-Fernández Luis A

Abstract excerpt

AIM: To find out whether SNPs in the transporter gene ATP-binding casette B1 (ABCB1) were related to adverse effects in colorectal cancer patients treated with 5-fluorouracil (5-FU) or capecitabine. MATERIALS & METHODS: Patients treated with a 5-FU-based therapy (n = 67) or a capecitabine-based therapy (n = 74) were recruited and genotyped for the ABCB1 SNPs rs1128503 (C1236T), rs2032592 (G2677T/A) and rs1045642...

Read the complete abstract on PubMed

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Topics

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Share to Antimetabolites, Antineoplastic
Share to ATP Binding Cassette Transporter, Subfamily B
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1
Share to Capecitabine
Share to Colorectal Neoplasms
Share to Deoxycytidine
Share to DNA
Share to Fluorouracil

Source

Identifiers

PMID: 21142915
DOI: 10.2217/pgs.10.159

Genes

ABCB1

Variants

rs1128503
rs1128503
rs1128503

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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