Article
Systemic inflammation and immune cell phenotypes are associated with neuro-psychiatric symptoms in patients with chronic inflammatory liver diseases.
Liver international : official journal of the International Association for the Study of the Liver - 1 Dec 2018
Aregay Amare, Dirks Meike, Schlaphoff Verena, Owusu Sekyere Solomon, Haag Kim, Falk Christine Susanne, Hengst Julia, Bremer Birgit, Schuppner Ramona, Manns Michael P, Pflugrad Henning, Cornberg Markus, Wedemeyer Heiner, Weissenborn Karin
Abstract excerpt
BACKGROUND & AIMS: Chronic inflammatory liver diseases are frequently associated with neuropsychiatric and cognitive dysfunctions. We hypothesized that symptomatic patients may show altered levels of soluble inflammatory mediators (SIMs) as well as changes in immune cell phenotypes. METHODS: A comprehensive immune-phenotyping including investigation of 50 SIMs as well as ex-vivo phenotypes of NK-cells, CD3+,...
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