Article
OK/basigin expression on red blood cells varies between blood donors and correlates with binding of recombinant Plasmodium falciparum reticulocyte-binding protein homolog 5.
Transfusion - 1 Aug 2018
Ye Luyi, Zhao Fengyong, Yang Qixiu, Zhang Jiamin, Li Qin, Wang Chen, Guo Zhonghui, Yang Ying, Zhu Ziyan
Abstract excerpt
BACKGROUND: Recently, basigin (BSG), which carries OK antigens on red blood cells (RBCs), was reported to be the receptor of the Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRh5). BSG-PfRh5 is the only essential receptor-ligand pair in P. falciparum invasion that is known to date. However, the kind of OK/BSG polymorphism involved in the selection pressure caused by P. falciparum malaria has not...
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