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Article

Differentiation of human embryonic stem cells into cells with corneal keratocyte phenotype.

PloS one - 1 Jan 2013

Chan Audrey A, Hertsenberg Andrew J, Funderburgh Martha L, Mann Mary M, Du Yiqin, Davoli Katherine A, Mich-Basso Jocelyn Danielle, Yang Lei, Funderburgh James L

Abstract excerpt

Corneal transparency depends on a unique extracellular matrix secreted by stromal keratocytes, mesenchymal cells of neural crest lineage. Derivation of keratocytes from human embryonic stem (hES) cells could elucidate the keratocyte developmental pathway and open a potential for cell-based therapy for corneal blindness. This study seeks to identify conditions inducing differentiation of pluripotent hES cells to...

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Source

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Identifiers

PMID: 23437251
DOI: 10.1371/journal.pone.0056831
PMCID: PMC3578879

Genes

NGFR
AQP1
BMI1
KERA
KIT
MSX1
NES
NOTCH1
NTRK3
SIX2
SNAI1
SOX9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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