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Article

KSHV induces immunoglobulin rearrangements in mature B lymphocytes

16 Apr 2018

Abstract excerpt

Kaposi sarcoma herpesvirus (KSHV/HHV-8) is a B cell tropic human pathogen, which is present in vivo in monotypic immunoglobulin λ (Igλ) light chain but polyclonal B cells. In the current study, we use cell sorting to infect specific B cell lineages from human tonsil specimens in order to examine the immunophenotypic alterations associated with KSHV infection. We describe IL-6 dependent maturation of naïve B...

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PMID: 29659614
DOI: 10.1371/journal.ppat.1006967

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