Article
Can chimerism explain breast/ovarian cancers in BRCA non-carriers from BRCA-positive families?
PloS one - 1 Jan 2018
Mitchell Rachel, Buckingham Lela, Cobleigh Melody, Rotmensch Jacob, Burgess Kelly, Usha Lydia
Abstract excerpt
Hereditary breast and ovarian cancer syndrome (HBOC) is most frequently caused by mutations in BRCA1 or BRCA2 (in short, BRCA) genes. The incidence of hereditary breast and ovarian cancer in relatives of BRCA mutation carriers who test negative for the familial mutation (non-carriers) may be increased. However, the data is controversial, and at this time, these individuals are recommended the same cancer...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.